FIVE POSTDOCTORAL POSTS IN STRUCTURAL AND MOLECULAR BIOLOGY: RESEARCH COMPLEX AT HARWELL (RCAH) AND WEATHERALL INSTITUTE OF MOLECULAR MEDICINE (WIMM) WITH DEPARTMENT OF CHEMISTRY, UNIVERSITY OF OXFORD.
Applications are invited for Postdoctoral Scientists (posts 1-3) for three years in an exciting new research programme to discover and develop small molecule inhibitors of mutant RAS for treatment of cancer. This new chemical biology drug discovery programme has co-investigators based at the Weatherall Institute of Molecular Medicine, the Research Complex at Harwell (RCaH) and the Department of Chemistry, Oxford, and is funded by the Wellcome Trust Seeding Drug Discovery Initiative. The aim of the project is to discover small-molecule drugs that inhibit protein-protein interactions involving the RAS family of proteins for treatment of cancer. The project will adopt a highly innovative strategy using single domain antibody fragments as tools for identification of drug-like molecules. Post 1 is for a structural biologist with a PhD in structural biology. Experience with solving structures using X-ray diffraction, crystallography of protein-ligand complexes, co-crystallisation and crystal soaking methods are essential. Experience with surface plasmon resonance and small molecule library screening will be advantageous. The post will be based in the laboratory of Professor Simon Phillips http://www.rc-harwell.ac.uk/directors.html at RCaH (adjacent to the Diamond Synchrotron). Informal enquiries may be made by email to simon.phill...@rc-harwell.ac.uk<mailto:simon.phill...@rc-harwell.ac.uk> and terence.rabbi...@imm.ox.ac.uk<mailto:terence.rabbi...@imm.ox.ac.uk>. Applications for this vacancy are to be made online. To apply for this role and for further details, including a job description and selection criteria, please use:- https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=106083 The closing date for this position is noon on Friday 08 March 2013. Please quote reference 106083. Posts 2 and 3 are suitable for molecular biologists with a PhD in molecular biology. Experience with recombinant protein production and purification, DNA transfection of mammalian cells, complex genetic engineering and site directed mutagenesis are essential. Experience with signal transduction cell biology, small molecule library screening and structural biology will be advantageous. The posts will be based in the laboratory of Professor Terry Rabbitts http://www.imm.ox.ac.uk/wimm-research/molhaem/terry_rabbitts at the Weatherall Institute of Molecular Medicine. Informal enquiries may be made by email to terence.rabbi...@imm.ox.ac.uk<mailto:terence.rabbi...@imm.ox.ac.uk>. Applications online at: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=106082 The closing date for these positions is midday on Friday 08 March 2013. Please quote reference 106082. Applications are also invited for two postdoctoral positions (Posts 4 and 5) in a new programme, funded by Leukaemia and Lymphoma Research, to discover and develop small molecule inhibitors of oncogenic proteins for the treatment of leukaemia/lymphoma. The posts will be available for 3 years in the laboratory of Professor Terry Rabbitts http://www.imm.ox.ac.uk/wimm-research/molhaem/terry_rabbitts. The aim of this project is to discover small-molecule drugs that inhibit protein-protein interactions involving transcription factor multi-protein complexes in leukaemia and lymphoma. The approach will involve novel strategies using single domain antibody fragments and peptide aptamers, as tools for the identification of drug-like molecules to lead the development for treatment of cancer. The programme involves structural determination of leukaemia proteins together with screening and characterization of small molecule inhibitors of protein-protein interactions. In particular, the project will use the structure of single antibody domains as templates for drug lead development. Posts 4 and 5 are for molecular biologists with a PhD in structural biology, experience with recombinant protein production purification and with solving structures using X-ray diffraction. Experience with surface plasmon resonance, AlphaScreen and other methods for small molecule screening and NMR are desirable. Informal enquiries may be made to Professor Terry Rabbitts at terence.rabbi...@imm.ox.ac.uk<mailto:terence.rabbi...@imm.ox.ac.uk>. Applications online at: https://www.recruit.ox.ac.uk/pls/hrisliverecruit/erq_jobspec_version_4.jobspec?p_id=106000 The closing date for these positions is noon on Friday 08 February 2013. Please quote reference 106000.
