Why not? They can be mutually excluding! If one is in, the second can be. This phenomenon brakes a local symmetry. FF
Dr Felix Frolow Professor of Structural Biology and Biotechnology, Department of Molecular Microbiology and Biotechnology Tel Aviv University 69978, Israel Acta Crystallographica F, co-editor e-mail: mbfro...@post.tau.ac.il Tel: ++972-3640-8723 Fax: ++972-3640-9407 Cellular: 0547 459 608 On Jan 7, 2013, at 11:28 , Xiaopeng Hu <huxp...@mail.sysu.edu.cn> wrote: > Dear All, > > We recently resolved an enzyme/inhibitor complex structure. The enzyme > contains two NCS related active site and we did find extra density in both of > them.However we observed that the two inhbitor moleculors are not NCS > related, but partly overlaped if make a NCS moleculor. Has anyone else > observed this before? Thanks for any help and suggestion! > > > Best, > > Xiaopeng Hu >