14-Sep-2012 21:50 Rehovot Dear Qiang A good example of just such a case is acetylcholinesterase, where homologous proteins have very similar electrostatic motifs, with an very large electric dipole, ~1,700. see three representative papers on this,
1. Ripoll, D. R., Faerman, C. H., Axelsen, P. H., Silman, I. & Sussman, J. L. (1993). An electrostatic mechanism for substrate guidance down the aromatic gorge of acetylcholinesterase. The Proceedings of the National Academy of Sciences U.S.A. 90, 5128-5132. 2. Felder, C. E., Botti, S. A., Lifson, S., Silman, I. & Sussman, J. L. (1997). External and internal electrostatic potentials of cholinesterase models. Journal of Molecular Graphics and Modelling 15, 318-327. 3. Botti, S. A., Felder, C., Sussman, J. L. & Silman, I. (1998). Electrostatic homology modelling of a set of ChE-like neural adhesion proteins identifies a shared 'annular' motif with ChEs. Structural implications for a cell-recognition role of ChEs. Journal of Physiology (Paris) 92, 414-416. best regards, Joel --------------------------------------------------------------------------------- Prof. Joel L. Sussman joel.suss...@weizmann.ac.il<mailto:joel.suss...@weizmann.ac.il> Pickman Prof. of Structural Biology +972 (8) 934 4531 - tel Head, The Israel Structural Proteomics Center (ISPC) +972 (8) 934 6312 - fax Department of Structural Biology www.weizmann.ac.il/~joel<http://www.weizmann.ac.il/~joel> Weizmann Institute of Science www.weizmann.ac.il/ISPC<http://www.weizmann.ac.il/ISPC> Rehovot 76100 ISRAEL www.proteopedia.org<http://www.proteopedia.org/> --------------------------------------------------------------------------------- On 14 Sep 2012, at 21:37, Qiang Chen wrote: Hi all, I'm working on a protein structure which showed a special electrostatic potential on its surface: positive on one end and negative on the other end. I wonder to what extent I can say this pattern is determined by the charged residues? If the residues are conserved, could I make a conclusion that its homologues also have such pattern? Thanks! The information in this e-mail is intended only for the person to whom it is addressed. If you believe this e-mail was sent to you in error and the e-mail contains patient information, please contact the Partners Compliance HelpLine at http://www.partners.org/complianceline . If the e-mail was sent to you in error but does not contain patient information, please contact the sender and properly dispose of the e-mail.
