A 2 year postdoctoral position with support from the French National
Research Agency (ANR) is available at the Institut de Biologie et Chimie
des Protéines, a mixed CNRS and University of Lyon 1 research institute
in Lyon, to study the human cytosolic 5’-nucleotidase II. This enzyme
plays an important role in the regulation of intracellular nucleotide
pools, and due to this regulatory activity, it is partly responsible for
the failure of some cancer treatments involving cytotoxic nucleoside
analogues.
With the aim of increasing the efficiency of these anti-cancer agents
currently used in the clinic, our studies involve a multidisciplinary
approach, which combines molecular and structural biology along with
classical biochemical procedures, bioinformatics and chemical synthesis.
The project is therefore conducted within a research consortium
gathering cellular-, molecular- and structural biologists but also
biochemists and chemists.
A Ph.D. in biochemistry or biophysics, and a solid experience in protein
expression, purification and X-ray structure determination are required.
Background knowledge in Small Angle X-ray Scattering techniques is an
advantage.
Salary is according to the CNRS guidelines.
Lyon is one of the major cities in France and is ideally located in the
centre of Europe within two hours of Paris, the Alps and the
Mediterranean. It has a strong cultural and intellectual tradition, is
widely known as the gastronomic centre of France, and the old town is a
UNESCO World Heritage site.
The position is immediately available and interested candidates should
send their CV, a letter of interest and contact information for 3
referees to Dr. Nushin Aghajari; n.aghaj...@ibcp.fr
