My understanding is that ML functions in the presence of pseudo-translational symmetry are suboptimal (see a very short discussion in Acta Cryst. (2011). D67, 355–367. Acta Cryst. (2008). D64, 99–107 is also a good reading). Having said that if your crystal/dataset exhibits twinning on top of pseduo-translation you should activate the twin refinement option in Refmac.
Roberto On 31 Jul 2012, at 10:47, Qixu Cai wrote: Dear all, Can I use the "twin refinement" to refine the pesudo-translational symmetry dataset? Thanks a lot for your help. Best wishes, Qixu Cai Roberto Steiner Randall Division of Cell and Molecular Biophysics King's College London Room 3.10A New Hunt's House Guy's Campus SE1 1UL, London, UK Tel 0044-20-78488216 Fax 0044-20-78486435 roberto.stei...@kcl.ac.uk<mailto:roberto.stei...@kcl.ac.uk>
