Structural biologists targeting breast cancer at Laval University Medical Center (CHUL, CHUQ)
Postdoctoral and Ph.D. positions are available at Laval University Hospital Research Center (CHUL, CHUQ), for the study of biological function of important enzymes and receptors implied in breast cancer development using structural biology, cell biology, genomics and proteomics. Our research involves related collaborative projects in steroid enzyme structure-function and in estrogen synthesis pathways, supported by the Canadian Institutes of Health Research (CIHR). Inhibitors of steroid enzymes will be searched for breast cancer treatment and will be tested in cancer cells and animal models. CIHR supported collaborative projects for anti-viral drugs are also available in the laboratory. Since our determination of the first human steroid enzyme structure, the type 1 17beta-hydroxysteroid dehydrogenase, we have analyzed a series of protein structures, resulting in leads for the cancer therapy. Expertise in one or two domains in crystallography, enzymology, cell biology, genomics and proteomics are highly welcome. Quebec City, with its original European style, is alongside the St. Laurence River, providing a beautiful and an excellent research environment. All positions will be well remunerated at CIHR levels, while the living expenses are modest in Québec City. For those who are interested in the above projects, please send your C.V. to sx...@crchul.ulaval.ca
