Hi, At 3.3A I would recommend trying a TLS model _instead_ of refining > individual B factors.
may be it is implementation/software/mindset dependent, but in phenix.refine refining TLS+individual ADP or simply individual ADP(*) is a better option most of the time at low resolution. For details see pages 30 and 31 here: http://phenix-online.org/newsletter/CCN_2010_07.pdf Pavel (*) ADP = Atomic Displacement Parameters
