Thanks, Artem! PDE2A also uses three domains to form a homodimmer. However, without the catalytic domain, the GAF B domain swings out. This is an excellent example for the restrictions set by the multidomain context.
Anyone knows other examples? Thanks a lot! > PDE2 full length versus domain only structures, I think. > > Artem > > On Thu, Jan 12, 2012 at 10:03 AM, Qiang Chen > <[email protected]>wrote: > >> Hi, >> >> I'm working on a multi-domain protein which uses three domains to form >> homodimer, and the full-length structure is available. We have solved >> the >> structure of one binding domain alone and found its homo-binding mode is >> totally different from that of the full-length protein. >> >> Do you know examples or papers discussing the similar subjects (crystal >> packing shows false binding mode)? >> >> Thanks a lot! >> >> Qiang >> >> >> >> The information in this e-mail is intended only for the person to whom >> it >> is >> addressed. If you believe this e-mail was sent to you in error and the >> e-mail >> contains patient information, please contact the Partners Compliance >> HelpLine at >> http://www.partners.org/complianceline . If the e-mail was sent to you >> in >> error >> but does not contain patient information, please contact the sender and >> properly >> dispose of the e-mail. >> >
