> How could they not be snapshots of conformations adopted in solution? Let me clarify--sorry about that. Consider several structures of the same protein solved under different conditions, or several homologs solved under similar conditions, or both. Further, let's say some structural element, perhaps a helix, assumes different mannerisms in the various structures. Can I reasonably assert that these structures are snapshots of the protein which would have existed under physiological conditions, and assemble the structures to a unifying conception of the helical motion, or must I assume these are artifacts of bizarre solution conditions, and one has nothing to do with the other? Or perhaps every case/protein is unique, in which case no general rule can be followed, amounting approximately to the same thing?
Jacob
