Do you have a list of dark-matter-aware PDB refinement programs?
Adding dark matter and refining in TNT or Xplor gives me exactly
the same R as without. Furthermore the final refined files have
lost the dark matter as far as I can see. This leads me to believe
these programs are completely ignoring the dark matter.
Ed
Ethan Merritt wrote:
Hi to all on ccp4bb:
What better day to announce the availability of a breakthrough technique
in macromolecular crystallography?
Given recent discussion and in particular James Holton's suggestion that
the problem of disordered sidechains is a problem akin to the difficulty
of describing dark matter and dark energy...
I am happy to announce a new crystallographic tool that can improve your
model by accounting for an often-neglected physical property. A detailed
explanation, references, and a preliminary implementation of the program
can be downloaded from
http://skuld.bmsc.washington.edu/DarkMatter
--
Ethan A Merritt
Karmic Diffraction Project
Fine crystallography since April 1, 2011
"What goes around, comes around - usually as a symmetry equivalent"
