Hi,
This is the first time I read about "shape complementarity statistics".
According to:
"A structural basis for the activity of retro-Diels–Alder catalytic
antibodies: Evidence for a catalytic aromatic residue"
As seen here:
http://www.pnas.org/content/99/15/9674.full
---
[...] compute the SHAPE COMPLEMENTARITY STATISTICS index (Sc). This
statistics index measures the geometric surface complementarity via the
use of normal products, and the extent to which the interacting surface
elements are brought into proximity via an exponential distance
separation term. Sc values usually range from 0.70 to 0.76 for
proteinase–protein inhibitor surfaces, from 0.64 to 0.68 for
antigen–antibody complexes, and from 0.45 to 0.70 for MHC–peptide
complexes (30).
---
I am frightened. :(
I don't think this is in my book "The cartoon guide
to statistics". Despite the book is really nice.
Regards,
F.
intekhab alam wrote:
I want to calculate the shape comlementarity statitics (SC) of a dimeric
protein using CCp4. I am using CCP4 6.1.3 on windows but the SC program
is not available in that suite.
Which version of CCP4 has that program. Are there any other programs
that can calculate that.
Thanks
--
INTEKHAB ALAM
LABORATORY OF STRUCTURAL BIOINFORMATICS
KOREA UNIVERSITY, SEOUL
