Dear All,

I would like to let you know that we have added many new features to the free ICM-Browser ( http://www.molsoft.com/icm_browser.html ) that will be useful for the crystallography community. The new free version of ICM-Browser and the ActiveICM plugin contains enhancements which allow you to create and save fully-interactive 3D molecular documents to display in PowerPoint and the Web (see some screenshots here http://www.molsoft.com/icm-browser-screenshots.html ). These new features make it easy to communicate chemical and protein structures clearly and effectively.

The ICM-Browser technology is already being used by PLoS ONE, PLoS Biology, and Molecular & Cellular Proteomics journals for publishing, and many pharmaceutical companies and academic labs use it for data sharing and high-quality molecular graphics. The SGC have been key in guiding MolSoft's development of this software and they use ICM-Browser technology to present their data to the public. The software runs on Linux, Mac, and Windows. Please join us at one of our free webinars, please register here http://www.molsoft.com/training.html

The new features include:

- Build and save fully-annotated and interactive 3D molecules and display them in Safari, Firefox, Google Chrome, and Internet Explorer.
- Display fully interactive molecules in Windows PowerPoint.
- Display ligand pocket surfaces colored by binding property.
- Add and optimize hydrogens to a PDB structure.
- Calculate and display hydrogen bonds.
- Generate and display molecule surfaces.
- Display transparent surfaces.
- Save publication quality molecular graphics files in a variety of image formats.

It is easy to get started:

1. Click here http://www.molsoft.com/getbrowser.cgi to download the ICM-Browser software and click here http://www.molsoft.com/getbrowser.cgi?product=activeicm&act=list to download the ActiveICM plugin.

2. Follow the documentation and videos here:

- ICM-Browser User Guide http://www.molsoft.com/gui/ICM-Browser-How-To.html for instructions on all the graphics features. - ActiveICM User Guide http://www.molsoft.com/gui/how-to-activeicm.html for instructions on how to display in PowerPoint and Web Browsers.

All the features in the previous version of ICM-Browser remain including:

- Powerful PDB search and download options.
- Full links to UniProt and PFam
- Label residues, atoms, and variables.
- 2D and 3D annotation.
- Measure and display distances and angles.
- Protein superposition.
- View and make high resolution images of alignments.

Any Questions? Contact Andrew Orry Ph.D. (andy<at>molsoft.com) 858-625-2000 x108

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