***********Director of Eukaryotic Protein Production*************
We seek a Director of Eukaryotic Protein Expression within the Macromolecular Therapeutics Development Facility (MTDF) at the Albert Einstein College of Medicine. The MTDF runs a high-throughput pipeline including automated cloning, expression and purification, as well as an active program focused on the development of novel protein expression/purification strategies in both prokaryotic and eukaryotic hosts. Our existing platforms support individual investigator initiated programs at Einstein and the greater New York Area, as well as a number of large-scale multi-institutional structural and functional genomics programs. The MTDF currently serves as the protein production core for both the New York Structural Genomics Research Consortium (NYSGRC), one of four high-throughput structure determination centers supported by the NIGMS Protein Structure Initiative, as well as the Enzyme Function Initiative, a large-scale NIGMS-supported program developing a general sequence/structure-based strategy for the discovery of enzyme function. The MTDF also serves as the eukaryotic expression core for the Northeast Biodefense Center, an NIAID Center of Excellence in biodefense and emerging infectious disease research, and supports the Immune Function Network which focuses on the structural and functional genomics of the innate and adaptive immune responses. In addition, the MTDF is establishing a high-throughput lentiviral-based shRNA screening core and will make available new technologies related to the use of RNA interference to investigators at the Albert Einstein College of Medicine and other institutions in the New York area.
We are seeking an exceptional individual for the position of Director of Eukaryotic Protein Expression to oversee the day-to-day operations of protein production and technology development programs. Specific duties include the oversight and further development of high-throughput platforms for eukaryotic expression, including the use of transiently and stably transfected Drosophila S2, CHO and HEK293T cell lines, as well as baculoviral- and lentiviral-driven expression systems. Additional efforts will focus on the creation and implementation of novel high-throughput approaches for eukaryotic expression.
A Ph.D. and at least four years of experience in eukaryotic protein expression is strictly required, as is previous experience with automation and robotics. As a significant element of our developing platform relies on baculoviral- and lentiviral-driven expression, previous experience with viral-based vectors, viral packaging and large-scale viral particle production is highly desirable.
The successful candidate will have strong organizational capabilities and the interpersonal skills required to interact with the leaders and members of a broad range of different research programs. The ability to work independently, and to supervise and manage multiple projects simultaneously is essential. Team membership skills are particularly important to ensure that these activities seamlessly integrate with the established programs, investigators and leadership within the MTDF.
The successful candidate will be appointed to a non-tenure track faculty position at the level of Associate. Salary is commensurate with experience and accompanied by a broad range of employee benefits. The Albert Einstein College of Medicine provides a highly stimulating academic environment and assures equal employment opportunities.
Interested candidates should forward a cover letter (describing training, background and accomplishments), curriculum vitae with bibliography and the names and contact information of three references to Dr. Ron Seidel, Associate Director, MTDF (rseidel_at_aecom.yu.edu) or Dr. Steve Almo, Scientific Director, MTDF (almo_at_aecom.yu.edu).
