The Structural Biology Laboratory at UT Southwestern Medical Center
currently has an opening at the Research Assistant Professor level for
a highly motivated individual who enjoys working in a collaborative,
multi-disciplinary setting. A Ph.D. in biochemistry, chemistry,
physics or a related field is required. Experience in structural
biology, particularly X-ray crystallography and protein expression/
purification is also required. Facility with related techniques such
as NMR or cryo-EM spectroscopy, small-angle X-ray scattering,
isothermal titration calorimetry or analytical ultracentrifugation is
highly desirable.
Demonstrable experience in all areas of X-ray crystallography,
including crystal growth and sample preparation, data collection on
home and synchrotron sources, structure determination and refinement
is required, and familiarity with the latest software is necessary.
Job requirements include a significant amount of both formal and
informal teaching, and travel to a synchrotron source with students
may be required several times per year. Salary is competitive and
commensurate with experience and qualifications.
About the Structural Biology Laboratory
The Structural Biology Laboratory (Diana Tomchick, Director) is a
platform that allows researchers with different expertise to come
together in a collaborative setting and tackle biological problems in
a comprehensive way. We use a multitude of experimental approaches,
mostly X-ray crystallography, but also NMR spectroscopy, complemented
by a plethora of biophysical and molecular-biological techniques.
State-of-the-art equipment is shared between the members in the
Structural Biology community at UT Southwestern and consists of one
Rigaku FR-E SuperBright high brilliancy X-ray generator equipped with
one set of high-resolution and one set of high-intensity X-ray optics,
two imaging-plate X-ray detectors (one R-Axis IV++ and one R-Axis IV),
two X-Stream crystal cooling devices, and one automated sample-
mounting device (ACTOR) for the unattended screening of crystals; a
Fluidigm microfluidics crystallization robot and imaging system; a
Phoenix crystallization robot, plus two Desktop Minstrel imaging
systems and a Gallery-160 Plate Hotel; 30 days per year of beamtime at
beamlines 19ID and 19BM at the Advanced Photon Source (APS), Argonne,
IL; several NMR spectrometers (one 800 MHz, three 600 MHz, two 500
MHz), cryo-probes and robotic sample changer. These facilities are
supplemented by a variety of biophysical instruments supporting the
study of macromolecules using CD, dynamic light scattering, analytical
ultracentrifugation, stopped-flow kinetics, isothermal titration
calorimetry and mass spectrometry.
The medical center has three degree-granting institutions: UT
Southwestern Medical School, UT Southwestern Graduate School of
Biomedical Sciences and UT Southwestern School of Health Professions.
Nearly 4,200 students are trained each year in graduate and allied
health programs, as residents and post doctoral fellows. Funding from
the NIH, foundations, individuals and corporations provide more than
$360 million annually for over 3,500 research projects.
Our faculty is comprised of many distinguished members, including:
four Nobel laureates, three of whom are active faculty members; 18
members of the National Academy of Sciences; and 18 members of the
Institute of Medicine.
Interested applicants should submit a curriculum vita and three
letters of reference by September 30, 2010 to Diana Tomchick, Chair,
Biophysics Search Committee, UT Southwestern Medical Center.
recruit...@utsouthwestern.edu
UT Southwestern is an Equal Opportunity/Affirmative Action Employer.
Women and minority candidates are encouraged to apply.
For further inquiries, please contact:
Diana Tomchick
Department of Biochemistry, Rm. ND10.214B
UT Southwestern Medical Center
5323 Harry Hines Blvd
Dallas TX 75390-8816
Tel. +1 214 645 6383
Email: diana.tomch...@utsouthwestern.edu
http://www8.utsouthwestern.edu/utsw/cda/dept16358/files/16776.html
http://www3.utsouthwestern.edu/sbl/
Some recent publications:
Scheuermann T.H. et al. (2009). Artificial ligand binding within the
HIF2a PAS-B domain of the HIF2 transcription factor. PNAS, 106:450-455.
Davis L. et al. (2009). Localization and structure of the ankyrin-
binding site on b2-spectrin. J. Biol. Chem., 284:6982-6987.
Yu, B. et al. (2010). Structural and energetic mechanisms of
cooperative autoinhibition and activation of Vav1. Cell, 140:246-256.
Shin O-H. et al. (2010). Munc13 C2B domain is an activity-dependent
Ca2+ regulator of synaptic exocytosis. Nat Struct Mol Biol 17:280-288.
Tian W. et al. (2010). Structural and functional analysis of the YAP-
binding domain of human TEAD2. PNAS, 107:7293-7298.
Luong P. et al. (2010). Kinetic and structural insights into the
mechanism of AMPylation by VopS FIC domain. J Biol Chem,
285:20155-20163.
Deng, X et al. (2010). Evolution of substrate specificity within a
diverse family of beta- and alpha-barrel fold basic amino acid
decarboxylases: X-ray structure determination of enzymes with
specificity for L-arginine and carboxynorspermidine. J Biol Chem,
285:25708-25719.
* * * * * * * * * * * * * * * * * * * * * * * * * * * *
Diana R. Tomchick
Associate Professor
University of Texas Southwestern Medical Center
Department of Biochemistry
5323 Harry Hines Blvd.
Rm. ND10.214B
Dallas, TX 75390-8816, U.S.A.
Email: diana.tomch...@utsouthwestern.edu
214-645-6383 (phone)
214-645-6353 (fax)
