Post-doctoral position in structural enzymology
A post-doctoral position will be available starting July 1, 2010 in
the group of Dr. Nicholas R. Silvaggi at the University of
Wisconsin-Milwaukee. Our lab uses X-ray crystallography, steady-state
enzyme kinetics, and complimentary biochemical and biophysical
techniques, to probe the structure and function of antibiotic
biosynthetic enzymes. Antibiotic resistance is a serious and
persistent problem that requires the continual development of new,
effective antibiotics. The ultimate goal of our research is to apply
lessons learned from natural product biosynthetic strategies to the
enzymatic or chemoenzymatic synthesis of new antibiotics.
The laboratory is located in newly-renovated space in the Department
of Chemistry and Biochemistry, which supports 23 enthusiastic faculty
members and 75 graduate students and postdoctoral researchers. The
department is connected to the Milwaukee Institute of Drug Discovery,
whose focus includes the development of new therapies for microbial
and parasitic diseases with an emphasis on multi-drug resistant
infections. More information about the department and laboratory can
be found at: http://alchemy.chem.uwm.edu and
http://alchemy.chem.uwm.edu/research/silvaggi. We have access to a
state-of-the-art Rigaku home source and dedicated beamtime at the
Advanced Photon Source (APS) through the LS-CAT.
The successful candidate will have received their doctoral degree in
biochemistry or biophysics by July 2010, possess excellent written and
oral communication skills, and perform well in a collaborative
environment. Previous experience with recombinant DNA techniques,
protein expression, and purification is required. Previous structural
biology experience is an advantage, but is not necessary. To apply,
please submit a cover letter including a brief description of research
experience, scientific interests, and training goals, a C.V. with a
list of publications, and contact information (e-mail address and
phone number) for three references to: silva...@uwm.edu. Informal
inquiries are welcome at the same address. Review of applications will
begin immediately and continue until the position is filled.
--
Nicholas R Silvaggi, Ph.D.
University of Wisconsin, Milwaukee
Department of Chemistry and Biochemistry
3210 North Cramer St
Milwaukee, WI 53211
Office: Chemistry 272B
Phone: 414-229-2647
silva...@uwm.edu
