Hello, I'm not entirely sure I know what you mean, but what came to my mind was malic enzyme. Check out Liang Tong's summary of structural data:
http://como.bio.columbia.edu/tong/Research/me.html This protein has 2 nucleotide binding sites, one in a canonical Rossman fold and another on the surface that is believed to be an allosteric site. However, I could be remembering this story wrong. --Paul --- On Tue, 10/20/09, Mark Brooks <mark.bro...@u-psud.fr> wrote: > From: Mark Brooks <mark.bro...@u-psud.fr> > Subject: Re: [ccp4bb] NADP - ADP binding > To: CCP4BB@JISCMAIL.AC.UK > Date: Tuesday, October 20, 2009, 7:42 AM > This is a good start for Rossmann > folds, I find. (I'm not sure if this > is what you want though.) > > "Chemical and biological evolution of a nucleotide-binding > protein." > Michael G. Rossmann, Dino Moras & Kenneth W. Olsen. > Nature Vol. 250 > July 19 1974, p194. > (Structural alignments in 1974 - wow!) > > If anyone has votes for other favourite papers of this ilk, > I'm all ears! > > Mark > > 2009/10/20 Vellieux Frederic <frederic.velli...@ibs.fr>: > > Michael Rossmann and colleagues did some work on the > binding of fragments of > > cofactors to dogfish lactate dehydrogenase. In the > 70's I think. Can be > > found on google scholar. Perhaps that's what you are > after? Can't find the > > reference right now (it's in one of my drawers but I > don't know which > > one...). I passed the reference on to Nicolas Coquelle > @ualberta > > (coque...@ualberta.ca) > a few days ago but that was from my home e-mail > > address so I don't have it here in the office. > > > > Fred. > > > > sajid akthar wrote: > >> > >> Dear All > >> > >> Can any one mention some reference regarding the > binding of NADPH or ADP > >> in the surface of the protein. Is there any rules > that dominate these two > >> cofactors to select the surface istead of typical > Rossmann fold. > >> > >> Thank you > >> > >> Sajid > >> > >> > >> > >> Yahoo! India has a new look. Take a sneak > peek > >> http://in.yahoo.com/trynew > >> > >> > >> > > > > > > > > -- > Mark Brooks, IBBMC, UMR8619 - Bâtiment 430, > Université de Paris-Sud, 91405 Orsay, France. > Tel: (33) 169157968 > Fax: (33) 169853715 > Skype: markabrooks >
