POSTDOCTORAL POSITIONS
for interdisciplinary research to uncover mechanisms of cyclic di-GMP
signaling
Four postdoctoral positions are available at the
Biozentrum of the University of Basel
within an interdisciplinary Sinergia project funded by the SNF, which
aims at understanding the molecular basis underlying the cellular c‐
di‐GMP signaling network in bacteria (for a recent review see:
Schirmer and Jenal, Nature Reviews Microbiology 7(2009)724 ).
Structural, dynamic, and functional aspects of c‐di‐GMP signaling
components are investigated embedded within an interactive environment
of research teams in computational,structural, and cellular biology.
Techniques include bioinformatics analysis, crystal structure
determination and homology modeling of representatives of the most
important signaling components. The conformational dynamics of these
components in solution will be addressed by single molecule FRET
experiments to understand their function and regulation. Mechanistic
models of catalysis and regulation will be validated and refined
systematically using in vitro and in vivo assays as readouts using
well‐developed pathogenic and non‐pathogenic model system for c‐
di‐GMP signaling.
We seek highly motivated and well‐trained individuals with a specific
interest in interdisciplinary research and close scientific
interactions. We offer full, long‐term SNF-funded positions with
competitive salaries and a highly dynamic and well‐equipped research
environment at the Biozentrum.
Position in molecular biology, microbiology, or biochemistry (group
Urs Jenal)
Candidates should have a strong background in protein biochemistry and/
or molecular biology techniques.
Position in structural biology or biochemistry (group Tilman Schirmer)
Experience in crystallographyand/or enzymology advantageous, but not
mandatory.
Position in biophysics, biochemistry, or molecular biology (group
Dagmar Klostermeier)
Candidates should have a strong background in optical spectroscopy,
preferentially at the single molecule level, and/or molecular biology
and protein biochemistry techniques.
Position in bioinformatics or computational biology (group Torsten
Schwede)
Candidates should have a strong background in protein sequence
analysis, data mining and/or computational structural biology.
Positions are available immediately. Please submit your application
letter including curriculum vitae, a brief description of previous
research experience, and contact information of two references to:
Yvonne Steger, Biozentrum University of Basel, Klingelbergstrasse
50/70 CH‐4056 Basel, Switzerland,
Email: bioinformat...@unibas.ch
For further information you may also contact the group leaders.
