[ccp4bb] B values bottomed out

[Gloria Borgstahl]

Hello ccp4-ers,

We are refining a 1.55 angstrom cryocooled structure with REFMAC.
In analyzing the occupancy of ligands in the active site we noticed
that all the residues there have bottomed out with an isotropic B value of 
2.0.
There is residual Fo-Fc density as the B values are not refined well.
How can one fix this?

Thanks, Gloria