Hi Shankar, Another fascinating example might be Dscam (Down Syndrome cell adhesion molecule) with multiple Ig like domains and Fibronectin type III domains. Different splice isoforms are expressed in different nerves, and it serves as a recognition module, same repels, different ones attract.
Not all the domains have been solved yet, and looking at the functional diversity, it is the small differences which are interesting in such case. There are also examples of "tandem" SH2, FHA, BRCT repeats, but it depends on how strict you are with the "identical". Cheers, Partha On Thu, Jul 2, 2009 at 6:39 AM, Shankar Prasad Kanaujia < spkanau...@gmail.com> wrote: > Dear CCP4 users, > Is there any multi-domain protein (with at least two domains) which has > identical tertiary structure of each domain ? > > Thanking you. > > -regards > shankar > > > -- MRC National Institute for Medical Research Division of Molecular Structure The Ridgeway, NW7 1AA, UK Email: pcha...@nimr.mrc.ac.uk Phone: + 44 208 816 2515
