For a classic example, how about going back to the very dawn of enzyme
crystallography and the avian lysozymes? e.g. chicken (128aa??? alpha+beta) and
Embden goose lysozymes (196aa?? all alpha) but with a conserved active site.
Again probably convergent evolution.
However, great examples of where the structure (and function) is conserved but
sequence has "completely" diverged (<10% identity) are in the
"super-evolutionary" viral world. Bamford and Stuart would be the authors to
look for here.
Cheers,
Robert
--
Dr. Robert Esnouf,
University Research Lecturer, Head of Bioinformatics and IT,
The Division of Structural Biology and
The Oxford Protein Production Facility,
The Henry Wellcome Building for Genomic Medicine,
Roosevelt Drive, Oxford OX3 7BN, UK
Emails: rob...@strubi.ox.ac.uk Tel: (+44) - 1865 - 287783
and rob...@esnouf.com Fax: (+44) - 1865 - 287547
