Employer: Imperial College London Website: http://www3.imperial.ac.uk/employment Location: South Kensington, London, SW7 2AZ Closing date: September 01, 2009 Requisition number: NS2009067AB
Research Associate in Time resolved Laue x-ray protein crystallography A Research Associate position is available in the Division of Molecular Biosciences at Imperial College London in the field of time resolved Laue X-ray crystallography of light sensitive proteins in the group of Dr. Jasper van Thor. The successful candidate will develop and employ experiments for time resolved X-ray diffraction using the pink-Laue technique at specialised beam line stations that combine pulsed broadband hard X-rays with pulsed optical excitation, at the SLS, APS and ESRF. The work will be conducted in a multidisciplinary environment which includes facilities for ultrafast electronic and vibrational spectroscopies to support the optical control of photolysis and reaction initiation in macromolecular crystals. The research deals with the light induced reactions in photoreceptors and fluorescent proteins and will focus on crystallisation of existing and new targets, analysis and optimisation of Laue diffraction, data processing and structure calculation of sub-ns intermediates. Additionally, the group provides support for ultrafast spectroscopic investigation of light induced reactions in targets and you will also work with members in the team on the spectroscopic characterisation and photolysis control. The successful candidate would have completed a PhD in Biochemistry, Chemistry or Physics or the equivalent in professional qualifications and experience and a have track record in Structural Biology. You will have extensive experience in monochromatic and/or Laue protein X-ray crystallography using synchrotron beam line stations or alternatively neutron diffraction. You will also have a proven track record in crystallographic data processing and structure calculation. Experience with molecular biology, protein purification and crystallisation is desirable but not essential. Experience in biomolecular spectroscopy would be an advantage but is not essential. Further details can be obtained from Dr Jasper Van Thor (j.vant...@imperial.ac.uk). Our preferred method of application is online via our website http://www3.imperial.ac.uk/employment.
