This is posted as a favor for a collaborator, please do not respond to
me but directly to Neal Alto.
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A postdoctoral research position is available in the laboratory of Dr.
Neal M. Alto, in the department of Microbiology, to study the
molecular mechanisms of bacterial type III effectors and specifically,
their ability to hijack human signal transduction cascades regulated
by Ras-family GTPases and actin cytoskeletal dynamics. The postdoc
will be responsible to build upon current biochemical and protein
interaction data to express, purify, crystallize, and perform
structural analyses involving bacterial type III effectors in complex
with human substrates. These studies will aim to complement ongoing
research using techniques in cell biology and microbial
pathogenesis. Additional project information can be found in [Alto
NM et al., Cell 2006] and [Alto NM et al., Journal of Cell Biology
2007].
The University of Texas Southwestern (UTSW) Medical Center is a world-
renowned research institute that is built upon foundations of
Biochemistry, Structural Biology, and Biomedical Research. Structural
studies will be performed in collaboration with the UTSW Structural
Biology Laboratory (SBL), a state of the art facility equipped with
modern X-ray crystallography equipment including a high-brilliance
Rigaku FR-E X-ray generator with an ACTOR crystal-mounting robot, an
integrated Phoenix crystallization robot and imaging system, and a
Fluidigm microfluidics crystallization robot and imaging system. The
Structural Biology Group at UTSW also has guaranteed access to 30 days
a year of beamtime at the Structural Biology center (SBC) at the
Advanced Photo Source (APS).
The minimal requirement is a Doctoral degree in protein chemistry or
molecular biology as well as prior experience in techniques of
molecular cloning, recombinant protein expression, and X-ray
crystallography. The successful applicant must be self-motivated,
enthusiastic and work well in a collaborative environment.
Competitive salary and fringe benefits will be provided based on UTSW
pay scale.
Interested individuals should submit a CV, a summary of research
achievements, and names of three references to:
Dr. Neal Alto (neal.a...@utsouthwestern.edu)
* * * * * * * * * * * * * * * * * * * * * * * * * * * *
Diana R. Tomchick
Associate Professor
University of Texas Southwestern Medical Center
Department of Biochemistry
5323 Harry Hines Blvd.
Rm. ND10.214B
Dallas, TX 75390-8816, U.S.A.
Email: diana.tomch...@utsouthwestern.edu
214-645-6383 (phone)
214-645-6353 (fax)
