Dear CCP4 users,
We have an opening at the ESRF Macromolecular crystallography group
(http://www.esrf.fr/UsersAndScience/Experiments/MX) for a Post-Doc to
work on *the role of membrane proteins in the resistance of
*/Deinococcus radiodurans/* to extreme conditions (see advert below).
The ESRF is located in one of the most scientifically stimulating and
beautiful places in Europe. *The Macromolecular Crystallography (MX)
group operates a world leading suite of synchrotron radiation beamlines
dedicated to the study of biological macromolecules and is also a member
of the (Partnership for Structural Biology, www.psb-grenoble.eu/) with
all the laboratory facilities you could need. Please follow the
instructions below to apply but feel free to email me with informal
enquiries. Many thanks, Matt.
Post-doctoral fellow (m/f) - Ref: 2312
in the Experiments Division
The ESRF is a multinational research institute, situated in Grenoble,
France and financed by 19 countries mostly European. It operates a
powerful synchrotron X-ray source with some 30 beamlines (instruments)
covering a wide range of scientific research in fields such as biology
and medicine, chemistry, earth and environmental sciences, materials and
surface science, and physics. Research at the ESRF is carried out by
several thousand external users each year from universities, public
research laboratories and industry, and by the ESRF's own scientists.
The ESRF employs about 600 staff and is organized as a French /société
civile/. The working language of the ESRF is English.
/The Experiments Division designs, constructs and runs the ESRF
experimental stations (= beamlines). Within this division the
Macromolecular Crystallography group is now seeking to recruit a:/
*Post-doctoral fellow (m/f)*
*THE FUNCTION:*
The subject of your research will be *the role of membrane proteins in
the resistance of */*Deinococcus radiodurans*/* to extreme conditions*.
The first line of defence to environmental shock are the surface layer
(or S-layer) proteins of the outer membrane. These proteins form
hexagonal crystalline planes covering the outer membrane acting as
protective layer with proposed roles as diverse as ion traps to that of
an exoskeleton. The S-layer has been studied extensively with a wealth
of biochemical data and its macrostructure has been investigated by
electron microscopy. However, molecular details of its assembly and
response to its environment remain unknown. The S-layer protein from
native /D. radiodurans/ membranes has been purified and we are
proceeding with structural studies. This project will be carried out in
the state-of-the-art CI Branden building (Partnership for Structural
Biology, http://www.psb-grenoble.eu/) as well as at the ITQB in Lisbon,
Portugal.
In parallel, you will also be required to participate in support
activities for external users on MX beamlines.
*QUALIFICATIONS AND EXPERIENCE:*
You should hold a PhD in Protein Crystallography, Molecular Biology or
Biochemistry with a strong background in structural biology. Additional
skills in molecular biology, recombinant protein expression and
purification and biochemical characterisation of membrane proteins are
highly desirable.
Only candidates holding a Ph.D. obtained less than 3 years ago are
eligible for Post-doctoral positions. Post-doctoral fellows are employed
for a two year-period with a possibility of extension to three years.
The contract will start as soon as possible.
Contact person: Matthew Bowler (bow...@esrf.fr <mailto:bow...@esrf.fr>),
Celia Romao (cmro...@itqb.unl.pt <mailto:cmro...@itqb.unl.pt>) or Sean
McSweeney (mcswee...@esrf.fr <mailto:mcswee...@esrf.fr>)
*ADDITIONAL INFORMATION:*
The ESRF shares a site with several other major European scientific
institutes; it offers an exciting opportunity in an international
atmosphere. New staff coming from outside the Grenoble area benefit from
installation allowances to move and settle in the area. An expatriation
allowance may be payable in accordance with specific regulations. Only
candidates holding a Ph.D. obtained less than 3 years ago are eligible
for Post-doctoral positions. /*Post-doctoral fellows are employed for an
eighteen-month period with a possibility of extension to another six to
eighteen months */and the contract should start as soon as possible. The
ESRF is an equal opportunity employer and encourages applications from
disabled persons.
*If you are interested, please send us a fax (+33 (0)4 76 88 24 60) or
an e-mail (**recru...@esrf.fr <mailto:recru...@esrf.fr>**) with your
address, and we will provide you with an application form. Or print out
an application form on the World Wide Web
http://www.esrf.fr/Jobs/Applying. In addition to the application form,
you should provide us with a detailed CV and the names of two referees.*
*Ref. 2312 - Deadline for returning application forms: 1 March 2009*
* *
/*Applications received after the deadline may be considered for the
selected vacancy if not filled or for future similar positions.*/
*Deadline:* 01-03-2009
*Contract type:* Non-permanent contract (CDD)
*Please send your application (form, covering letter and CV) to: *
Louise Peritore-Niang
<javascript:write('peritore','esrf.fr','Post-doctoral%20fellow%20(m/f)')>
--
Matthew Bowler
Macromolecular Crystallography Group
European Synchrotron Radiation Facility
B.P. 220, 6 rue Jules Horowitz
F-38043 GRENOBLE CEDEX
FRANCE
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Tel: +33 (0) 4.76.88.29.28
Fax: +33 (0) 4.76.88.29.04
http://www.esrf.fr/UsersAndScience/Experiments/MX/
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