> to my knowledge, none of the existing reciprocal-space refinement > programs is really suitable for low-resolution refinement. In my
For what it's worth, I've had good luck with refmac5D, which incorporates an SAS target into model refinement (I believe this was has now been incorporated into the mainstream refmac branch semi-recently). Making full use of the chemistry/geometry information is important, but so is using as many observations as you can get your hands on. Pete
