I would say that all crystals represent hyper-oligomeric structures,
but never mind, I know what you mean ;-)
the E. coli EF-Tu:EF-Ts complex is a good example - the structure
clearly indicates an (EF-Tu:EF-Ts)2 dimer, and the T. thermophilus EF-
Tu:EF-Ts is even a disulphide-linked dimer.
However, all solution studies indicate that the E.coli EF-Tu:EF-Ts
complex is in fact a monomeric complex.
Poul
On 11/12/2008, at 17.09, Santarsiero, Bernard D. wrote:
In parallel with the discussion around this off-CCP4-topic, are they
any
good examples of the opposite case, where the protein is a monomer in
solution (as evident from light scattering, MW determination through
centrifugation, EPR, etc.) but crystallizes as a dimer or higher
multimer?
Bernie Santarsiero
