As long as each residue within a chain has a unique identifier
(residue number plus insertion code), there is no restriction
on numbering. The numbers can be in ascending or descending
order, non-sequential, and even negative.
Frances
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On Fri, 19 Sep 2008, Todd Geders wrote:
Hello all,
I have a structure from a non-natural fusion of the truncated C-terminus of
one protein with the truncated N-terminus of another. For the deposition, we
want to keep the numbering as found in the separate proteins. It looks
something like this:
1 12
| |
....HWVCKDIALLMCFFLEEMSEEP....
| |
754 763
At no point is there an overlap in numbering (i.e. the N-terminal residue
number is higher than the C-terminal residue number).
Is this numbering scheme supported by the PDB standard? Thus far, all of the
software seems to handle it (refmac, Coot, PyMOL, pdb_extract, PDB precheck &
validation, etc).
Can anyone see a reason to not deposit with this non-sequential residue
numbering?
~Todd
