Applications are invited for a Ph.D. studentship in the research field
of structure-based drug design available at the Institute of
Biochemistry, University of Luebeck, Germany.
The announced position will be funded for three years by a grant from
the Luebeck Graduate School "Computing in Medicine and Life Sciences"
(www.gradschool.uni-luebeck.de <http://www.gradschool.uni-luebeck.de>).
The Graduate School was established within the scope of the excellence
initiative initiated by the German Federal Government and the German
Research Foundation (DFG).
The Institute of Biochemistry possesses a long-standing reputation for
research on the molecular basis of intracellular infections by RNA
viruses (particularly coronaviruses including the SARS virus), bacteria
and protozoa, with the objective to design and develop new antiinfective
drugs (e.g. EMBO J. 21, 3213 (2002), Science 300, 1763 (2003), PNAS 100,
13190 (2003), Cell 117, 57 (2004), JMB 354, 25 (2005), JBC 281, 25425
(2006), Chem Biol 15, 597 (2008)).
In the near future, these research activities should be extended to drug
targets of disease-relevant flaviviruses, particularly Dengue, West
Nile, and Hepatitis C viruses, with special focus on structure-guided
design of lead compounds possessing inhibitory activity.
The successful candidate will gain experience in a broad variety of
experimental and computational techniques such as molecular cloning,
recombinant protein expression, purification, crystallization, data
collection, structure solution and model building, preparation of
protein-ligand complexes, virtual screening for lead- and fragment-like
inhibitors, molecular dynamics calculations, biochemical assays,
crystallographic fragment screening as well as characterization of
protein-ligand interactions by isothermal titration calorimetry.
We are building an outstanding program for the discovery of new
antiinfectives, with various techniques for preclinical research
available in-house. Investigations include the identification of
potential virulence proteins by proteomics, crystallization, and X-ray
structure determination, as well as the design and chemical synthesis of
inhibitors. The institute is well equipped with crystallization
facilities such as crystallization robots and imaging systems. We also
operate an outstation at DESY (Hamburg) with direct access to
synchrotron radiation.
Practical basic skills in molecular-biological techniques would be desired.
Applicants interested in the announced position are invited to send
their complete resumé according to the admission conditions of the
Graduate school http://www.gradschool.uni-luebeck.de/?q=node/20) in
electronic form to [EMAIL PROTECTED]
<mailto:[EMAIL PROTECTED]>**. *
--
Dr. Holger Steuber
Professor(W1) for Structure-based Drug Design
Institute of Biochemistry
University of Luebeck
Ratzeburger Allee 160
23538 Luebeck
Germany
Phone : +49-451-500-4065
Fax : +49-451-500-4068
E-mail : [EMAIL PROTECTED]
