[ccp4bb] S-Met replacement

[Joerg Stetefeld]

  Dear All

  what are the experiences in the community in terms of  
physico-chemical property changes if one replace a S-Methionine by a  
Se-Methionine?

  Are there structural  a/o functional changes known, e.g. the wild type 
protein binds a ligand whereas the Se-Met version does not?

thank you in advance

Jörg Stetefeld, Ph.D.