POSTDOCTORAL POSITION AVAILABLE The Structure and Function of Membrane Biology Laboratory (SFMB) is focused on understanding how membrane proteins work, using a combination of structural and functional approaches. The SFMB is affiliated with the Université Libre de Bruxelles and is located in Brussels, Belgium.
A main focus of the lab is the study of multidrug transporters responsible for chemoresistance in cancer therapy or antibiotic treatments. In collaboration with four other laboratories, we are starting a project aiming at deciphering the structure of ATP-binding cassette transporters and secondary transporters, and will develop new diagnostic tools and therapeutic approaches. An array of highly specific recombinant antibodies will be generated against the targets (including, among others, P-gp and MRP1). These reagents will be used, on one hand, as putative diagnostic and/or therapeutic tools against multidrug resistance and, in parallel, as crystallization aids in an effort to obtain high-resolution structure of the targets. A three years postdoctoral position is available as of June 1st 2008 to study the structure and function of a set of key ABC transporters involved in resistance to chemotherapy. The postdoc will be in charge of production and purification of the targets from existing strains, characterize the diagnostic and therapeutic potential of the antibodies and take part in the crystallization effort. The work will be geared both towards a better understanding of the function of the transporters (basic science) and the development of diagnostic and therapeutic tools (applied science). Candidates should have a recent PhD and have a strong background in structural biology, protein expression and purification, preferably with membrane proteins; molecular biology skills are a plus. Candidates should not be Belgian nationals. Applications: Send a CV, a list of publications, a short overview of research activities and the name of two to three references to [EMAIL PROTECTED] or [EMAIL PROTECTED] Preselected applicants will be requested to travel to Brussels for a lecture and an interview. -- Marc F. Lensink Centre for Structural Biology and Bioinformatics CSBB Université Libre de Bruxelles [EMAIL PROTECTED] Boulevard du Triomphe - CP 263, B-1050 Brussels, Belgium tel: +32 2 650 5411 secr: +32 2 650 2013 fax: +32 2 650 5425
