Post-doctoral Training Fellow - Structural Biology of Mitotic Regulation
Section of Structural Biology, The Institute of Cancer Research,
Chester Beatty Laboratories, Chelsea, London
The Institute of Cancer Research (a College of the University of
London) is a world-class cancer research organization with HEFCE RAE
ratings of international excellence across all of its research
programmes. In partnership with The Royal Marsden NHS Foundation
Trust, we form the largest comprehensive cancer centre in Europe,
dedicated to research that extends from epidemiology, genetics and
molecular biology, through drug discovery and development, to cancer
diagnosis and patient treatment. This makes us uniquely placed to
work towards our vision that people may live their lives free from
the fear of cancer as a life threatening disease.
This Cancer Research UK funded position will investigate the
structure and function of the Chfr protein (Checkpoint with Forkhead
and RING domain), a ubiquitin E3 ligase and tumour suppressor
involved in mitotic regulation. Chfr is crucial for a mitotic
checkpoint that produces a cell-cycle delay in response to
microtubule poisons. The successful applicant will determine crystal
structures of Chfr bound to its protein partners and investigate the
structural and cellular mechanisms of Chfr activity and regulation.
The project is a collaboration between Dr Richard Bayliss (Structural
Biology), Prof. Richard Marais (Cell and Molecular Biology) and Dr
Spiros Linardopoulos (Breakthrough Breast Cancer).
Applicants must hold a PhD, or be close to completing their PhD
studies, in biochemistry, molecular biology or structural biology.
Experience in molecular biology, protein expression and purification
is essential. Experience in crystallographic structure determination
using SAD/MAD/MIR techniques would be considered an asset.
The position is offered on a fixed term contract of up to three years
in the first instance with a starting salary in the range £26,597 to
£31,551 p.a. inclusive.
Informal enquires may be made to Dr Richard Bayliss (Tel: +44 (0)20
7153 5557 / Email: [EMAIL PROTECTED]). Please DO NOT send
your application to Dr Bayliss; CVs must be submitted in line with
the instructions below.
For further particulars and details of how to apply, please visit our
website at www.icr.ac.uk. Alternatively you may call our 24 hour
recruitment line on 020 7153 5475 quoting reference number C128.
Closing date: Friday 4th April 2008
The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company
Limited by Guarantee, Registered in England under Company No. 534147 with its
Registered Office at 123 Old Brompton Road, London SW7 3RP.
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