Structural Studies on Human Proteins of Medical Relevance Karolinska Institutet, Structural Genomics Consortium Department of Medical Biochemistry and Biophysics
Web link: http://sgc.ki.se/jobs.html Structural Biochemistry of Integral Membrane Proteins (2 positions) We seek two talented researchers for our post-doc programs on human integral membrane proteins 1. Membrane protein chemistry/structural biology. The applicant should have strong background in recombinant membrane protein production in E. coli, preferably with some experience of protein crystallisation. Main aims include the implementation of new and improved methods for purification and crystallisation of integral membrane proteins. Knowledge about X-ray crystallography would be an advantage but is not a requirement. 2. Membrane protein X-ray crystallography. The applicant should have a strong background in X-ray crystallography with a good track record. Main tasks are crystallisation screening, crystal optimisation, data collection and structure determination of integral membrane proteins. Previous experience with membrane proteins would be an advantage but is not a requirement. Supervisor: Prof. Pär Nordlund, Starting date: No later than October 2008 Structural Biochemistry of Metabolic/Signalling Proteins (1 position) We seek a talented researcher to join our program on human metabolic/signalling proteins, including areas such as phosphoinositide signalling, lipid metabolism and lipid transport. The postdoc is expected to contribute to collaborative research on proteins from our target list, as well as in-depth studies on a sub-set of proteins. This includes expression, purification, characterisation, crystallisation and structure determination of target proteins as well as functional characterisation. Suitable candidates have a PhD in a relevant area, preferably within Molecular Biology, Biochemistry, Structural Biology or related subjects and a strong publication record. A strong background within X-ray crystallography would be and advantage. Supervisor: Assoc. Prof. Helena Berglund, Starting date: No later than October 2008 X-ray crystallography (1 position) The X-ray crystallography program is dedicated towards high throughput protein crystallisation, data collection and structure determination and requires a strong background in X-ray crystallography. Main aims include the implementation and application of parallel (high throughput) methods for X-ray crystallography and structure determination of human proteins. The Core Crystallography unit is expected to contribute senior expertise in the structure determination process and is often exposed to the more challenging structure determination/refinement projects. Supervisor: Dr. Martin Moche, Starting date: No later than October 2008 All SGC research is carried out by teams in a highly collaborative manner, and applicants must therefore have strong interpersonal skills as well as the ability to work independently. For a list of SGC publications, please visit: http://www.thesgc.com/publications/ The positions are offered for 2 years, and general requirements to be eligible to apply are a Non-Swedish citizenship and a Doctoral degree from a University outside Sweden. For further information, or to apply, contact Dr. Johan Weigelt, Chief Scientist (+46 8 524 86840, [EMAIL PROTECTED]). The application should contain a short CV, an outline of primary research interests and a list of at least two reference persons. Applications deadline: March 16, 2008 The Structural Genomics Consortium (SGC) is a not-for-profit organization that aims to determine the three dimensional structures of proteins of medical relevance, and place them in the public domain without restriction. The SGC operates out of the Universities of Oxford and Toronto and Karolinska Institutet, Stockholm. During the first phase of the project, more than 450 protein structures were deposited in the PDB. In its second funding phase (July 1 2007 - June 30 2011) SGC aims to determine more than 650 novel structures, including 9 structures of human integral membrane proteins. SGC works on a Target List of ~2,400 proteins with relevance to human health comprising proteins associated with diabetes, cancer, genetic and epigenetic disease as well as with infectious diseases such as malaria. __________________________________________________ Martin Moche, Ph.D., M.Sc. Senior scientist Karolinska Institutet MBB/SGC Scheeles väg 2 171 77 Stockholm Sweden Phone: +46-8-524 868 43 Mob: +46-733-229327 Fax: +46-8-524 868 68 [EMAIL PROTECTED]
