Dear Brad, the flexibility, that is how far a protein is stabilized with cold and heat denaturation of a protein,
this inturn depends on 1.solvation enthalpy of nonpolar moieties(need more energy,so there needs to be some randomness) 2.shift in temparature due to the enthalpy associated with transfer of peptide group into water 3.its all depend truly on enthalpy convergence temperature and entropy convergence temperature. infact both quantities are characterised with large enthapy and entropy compensation and; the temperature. thanks On Nov 13, 2007 6:07 PM, Ethan Merritt <[EMAIL PROTECTED]> wrote: > On Tuesday 13 November 2007 06:41, Brad Bennett wrote: > > > > I would be interested then to know how the community feels about the > > correlation of B-factors to protein flexibility. It is generally > accepted > > that these are linked but are there any new papers that address this? > > This is the basis of TLSMD analysis, and TLS refinement in general. > TLSM is described in > Painter & Merritt (2006) Acta Cryst. D62, 439-450 > > <http://skuld.bmsc.washington.edu/~tlsmd<http://skuld.bmsc.washington.edu/%7Etlsmd> > > > > > -- > Ethan A Merritt Courier Deliveries: 1959 NE Pacific > Dept of Biochemistry > Health Sciences Building > University of Washington - Seattle WA 98195-7742 > -- S.Jayashankar Research Student Institute for Biophysical Chemistry Hannover Medical School Germany
