Postdoctoral Training Fellow
Structural Biology of Hsp90 – Client Protein Complexes
Section of Structural Biology
The Institute of Cancer Research
Chester Beatty Laboratories
Chelsea, London
The Institute of Cancer Research is one of the world's leading cancer
research
organisations and is internationally renowned for the quality of its
science. Our mission
is the relief of human suffering by pursuing excellence in the fight
against cancer.
A Wellcome Trust-funded Postdoctoral position is available from 1st
October 2007 in
Professor Laurence Pearl’s group in the Section of Structural
Biology, to study the
structural basis for regulation and activation of ‘client’ proteins
by the Hsp90 molecular
chaperone system. The Postdoc will be responsible for expression,
purification,
crystallization and structural analysis of protein complexes
involving the Hsp90
molecular chaperone, co-chaperones and client proteins (such as
protein kinases) that
depend on Hsp90 for their biological function.
The Section of Structural Biology at ICR is exceptionally well
equipped for all aspects of
modern structural biology, with state-of-the-art laboratories for
molecular biology,
recombinant expression in bacterial and eukaryotic systems,
biochemistry, X-ray
crystallography and electron microscopy.
Applicants must have a PhD in a biological science, and experience in
recombinant
expression, protein purification, crystallisation and X-ray
crystallography. Information on
our previous work in this field can be found by searching PubMed and
via our Home
Page http://www.icr.ac.uk/structbi/
The starting salary for the position will be in the range £28,050 to
£35,400 p.a. inclusive
(based on previous post-doctoral experience) and the post is offered
initially on a fixed
term contract of up to 4 years. Informal enquiries to
[EMAIL PROTECTED] Please
DO NOT send your application to Professor Pearl; CVs must be
submitted in line
with the instructions below.
To apply, please send two copies of your CV and covering letter
(incl. the names
and addresses of two referees) together with a completed Equal
Opportunities
Monitoring Form to the HR Office, The Institute of Cancer Research,
123 Old
Brompton Road, London SW7 3RP quoting job Ref. C48.
Closing date: 6 August 2007
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Laurence H. Pearl PhD FMedSci
Professor of Protein Crystallography and Section Co-Chairman
Section of Structural Biology, Institute of Cancer Research
Chester Beatty Laboratories, 237 Fulham Road, London SW3 6JB, UK
Phone +44-(0)20 7153 5422 : Secretary +44-(0)20 7153 5443
FAX +44-(0)20 7153 5457 : E-Mail [EMAIL PROTECTED]
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" Live Simply and do Serious Things .. " - Dorothy Crowfoot Hodgkin
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The Institute of Cancer Research: Royal Cancer Hospital, a charitable Company
Limited by Guarantee, Registered in England under Company No. 534147 with its
Registered Office at 123 Old Brompton Road, London SW7 3RP.
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