Probably. Many others can be solved by molecular replacement, even with a very crude starting model.
Recently we solved a 142 nucleotide ribozyme dimer, a novel structure with no useful NCS symmetry, with just a native data set, A-form helical fragments generated in coot, and an irritable, cantankerous, impatient, sleep-deprived disposition. Shane Atwell wrote: > A friend of mine asked me whether small nucleotide duplexes can be > solved by direct methods. I think their data is 2.0A. >
