------------------- STRUCTURAL IMMUNOLOGY ---------------------- Positions are now available to study the structure, function and therapeutic application of T cell costimulatory molecules in the Nathenson and Almo laboratories at the Albert Einstein College of Medicine. We employ a multi-disciplinary approach that includes traditional high resolution crystallography, fluorescence microscopy, FRET, cell-based and whole animal studies. The ideal candidate will have considerable experience in protein production in both bacterial and eukaryotic platforms and a strong interest in defining the fundamental mechanisms that modulate the cellular immune response.
These positions are supported by an NIH-funded Training Grant in Immuno-Oncology and require either US citizenship or permanent residence status. Interested individuals should send a CV and arrange for three letters of reference to be sent to [EMAIL PROTECTED] Representative examples of our program are provided by the following references: Schwartz, et al., (2001) Structural Basis for Costimulation by the Human CTLA-4/B7-2 Complex. Nature 410: 604-608. Zhang, X., et al. (2004) Structural and Functional Analysis of the Costimulatory Receptor Programmed Death-1. Immunity 20: 337-347. Bhatia, S., et al. (2005) Different Cell Surface Oligomeric States of B7-1 and B7-2: Implications for Signaling. Proc. Natl. Acad. Sci. USA 102: 15569-15574. Cao, E., et al. (2006) NTB-A Crystal Structure: Implications for Homophilic Interactions and Signaling by the SLAM Family of Receptors. Immunity 25:559-570. Chattopadhyay, K., et al. (2006) Structural basis of inducible costimulator ligand costimulatory function: determination of the cell surface oligomeric state and functional mapping of the receptor binding site of the protein. J Immunol. 177:3920-3929. Cao, E., et al. (2007), T cell immunoglobulin mucin-3 crystal structure reveals a galectin-9-independent ligand-bindng surface, Immunity 26:311-21.
