A small comment: crystals that do not diffract well at R.T. can still diffract well when frozen. There are several reasons for this, including:
* poor stability of crystal once the drop is open to the air * crystal has low tolerance for handling (capillary mount can be challenging and cause more physical damage, especially if the experimenter is rusty with capillary mounts) * the effect of freezing - it has been known to cause transitions between space groups etc. * the effect of cryoprotectant (dehydration, and so forth) So - even if your stuff doesn't diffract well in a capillary - it still can be saved sometimes :) Or not. Artem > diffracts in general. It is true it may be a cryo problem, but if > the non cryo protected crystals do not diffract then why would one > expect the cryo protected one to.
