Sorry for the late reply, but I wanted to wait a few days before giving 
feedback.
I can confirm that -tcplro on the vio(4) interface solved the issue for me.
The server has an uptime of ~7 days now.


> On 24. Oct 2024, at 12:17, Stuart Henderson <s...@spacehopper.org> wrote:
> 
> On 2024/10/23 22:36, Oliver Schweger wrote:
>> I’ll test your recommendations over the next few days, but I don’t expect 
>> -tcplro to make any difference, as wireguard only uses udp.
> 
> However TCP can be carried inside wg. And some things are carried from
> an "inner" packet to a packet carried in some outer layer. I've not
> looked at how things are done with wg(4) but it's not impossible that
> something is carried across which shouldn't be.
> 
>> For the nic, I can choose between virtio, e1000, and rtl8139, so I’ll be 
>> testing each one individually, both with and without ipv6.
> 
> People have definitely reported issues where some em(4) and some vio(4)
> are involved. However there are various complexities: firstly these
> drivers support various different types of interface with different
> options, secondly the interface type where a packet is *received* is
> involved. So for example a packet rx'd on some interface, wrapped in
> wg(4), then tx'd on a TSO interface, may result in different behaviour
> depending on whether the rx interface has LRO or not.

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