Similar issue reported: https://lists.gnu.org/archive/html/help-guix/2025-03/msg00151.html
Additional details:
$ echo $GIO_EXTRA_MODULES
$ guix shell epiphany --search-paths
export
PATH="/gnu/store/a4pnp03dn5xp16d2w72m0vsfmwlkk0xc-profile/bin${PATH:+:}$PATH"
export
XDG_DATA_DIRS="/gnu/store/a4pnp03dn5xp16d2w72m0vsfmwlkk0xc-profile/share${XDG_DATA_DIRS:+:}$XDG_DATA_DIRS"
export
GIO_EXTRA_MODULES="/gnu/store/a4pnp03dn5xp16d2w72m0vsfmwlkk0xc-profile/lib/gio/modules${GIO_EXTRA_MODULES:+:}$GIO_EXTRA_MODULES"
$ guix shell epiphany
[env]$ echo $GIO_EXTRA_MODULES
/gnu/store/a4pnp03dn5xp16d2w72m0vsfmwlkk0xc-profile/lib/gio/modules
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