knot-resolver-service-type by default is configured to bootstrap the root trust anchors which fails since it depends on 'lua-http' which is missing from guix.
/var/log/messages snippet: --8<---------------cut here---------------start------------->8--- Feb 4 17:43:26 localhost shepherd[1]: Service kresd has been started. Feb 4 17:43:26 localhost shepherd[1]: [kresd] [system] warning: hard limit for number of file-descriptors is only 4096 but recommended value is 524288 Feb 4 17:43:26 localhost shepherd[1]: [kresd] [system] error while loading config: ...-knot-resolver-5.5.3/lib/knot-resolver/trust_anchors.lua:336: [ ta ] fetch of "https://data.iana.org/root-anchors/root-anchors.xml" failed: error: lua-http and luaossl libraries are missing (but required) Feb 4 17:43:26 localhost shepherd[1]: [kresd] [ ta ] Failed to bootstrap root trust anchors! (workdir '/var/cache/knot-resolver') Feb 4 17:43:26 localhost shepherd[1]: Service kresd (PID 7870) exited with 1. Feb 4 17:43:26 localhost shepherd[1]: Service kresd has been disabled. Feb 4 17:43:26 localhost shepherd[1]: (Respawning too fast.) --8<---------------cut here---------------end--------------->8---