I have been noticing many warnings coming from R in several contexts saying:
WARNING: ignoring environment value of R_HOME See for example the output of running: $ R --version This warning appears to be coming from line 69 of ess-r-gui.el where an unset environment variable R_HOME is being set in elisp code which is pointing to some ancient version of R located inside a Microsoft Windows file system: R_HOME="c:/progra~1/R/R-2.6.1" This whole ess-r-gui.el file seems to be dedicated to interfacing with software in Microsoft Windows which doesn't seem at all relevant in the Guix world. This whole file can probably be safely deleted along with line 164 in the ESS/lisp/Makefile which I think triggers byte compilation.