Hello. Looks like commit de477809d77393b8fb00d99cd35d65f77d157726 by Sou Bunnbu should have fixed this.
Validating using a current guix that icons load in wxmaxima without having to load in anything else: ----- guix --version guix (GNU Guix) e7a7a483bcda6ec60d9dff3b3aba88dababe035c $ guix environment --pure --ad-hoc wxmaxima -- wxmaxima ----- Chris Marusich's suggestion to install an icon theme package into your profile will help with most other general icon issues. Going to go ahead and close. (note: there is bug#39955 to address the broken help menu)