I regularly run this command: ./pre-inst-env guix refresh -t cran,bioconductor -u
This makes a lot of HTTP requests to check for updates. It often aborts with this error before it can finish checking for updates of all packages: guix refresh: error: open-file: Too many open files: "/home/rekado/.cache/guix/http/EXpQeEGkSNjRNVeWpGMNV8ENjJfhl2vugsTbrdaTshg=" -- Ricardo