Hello Guix! After brief discussion on IRC channel, I found out that adding "pinentry-program /home/user/.guix-profile/bin/pinentry-program" to "gpg-agent.conf" in "/home/user/.gnupg", was able to temproarily resolve the situation. Thanks to Ricardo (rekado).
I still suggest that there should be a default/fallback option for this. After reviewing guix repository, I found pinentry, emacs- pinentry, pinentry-tty, pinentry-qt, pinentry-gtk2, pinentry-gnome3, pinentry-emacs and pinentry-efl, as available pinentry programs. Out of all, I suggest pinentry to be set as default/fallback option for gnupg in guix, as it is platform-independent and provides both CUI (console) and GUI. Thank you! Regards, RG.