Hey Matthew,
I have successfully used slock on a Guix system, but I haven't
tried using the Guix slock on a foreign distribution. I would
expect it to not work, and the error message gives us an idea why:
When using the guix installed slock, it doesn't lock the screen,
and errors with the following error: "slock: unable to disable
OOM killer. Make sure to suid or sgid slock."
None of the programs in the Guix store (ie. /gnu/store) will have
setuid or setgid set. On a Guix system you can install a slock
screen-locker-service, which will provide a setuid binary for
slock (via the setuid-program-service). This is done automatically
as part of the default %desktop-services. I don't know of a way to
do this on a foreign distribution.
Carlo