Hi Ludo, I can confirm that the error disappears when nscd is running. Emacs no longer tells me
Error (initialization): User rwurmus has no home directory when starting it as long as nscd is running. I would like to note that the version of Emacs that is available through Fedora repositories does not need nscd to run (this is on the same machine). The error only appears when nscd is not running and the Emacs installed via Guix is used. Thanks for the help! Now that I’m sure that this is not a general problem I can prepare to replace Fedora with GuixSD on my office workstation. ~~ Ricardo