The GUILE_ENABLE_JIT m4 macro should _not_enable JIT on the Apple silicon. That's going to take a real port.
This may help in detecting the M1 as long as build==host. apple_silicon=`sysctl machdep.cpu.brand_string 2>/dev/null | grep -i -c "Apple M1"` If a cross-compile is happening, then TARGET_OSX and MAP_JIT macros may help. Jeff