Here is a patch that gets mine working. Not sure it solves all the Sierra issues.
*** libguile/filesys.c-orig 2016-11-05 07:49:09.000000000 -0700 --- libguile/filesys.c 2016-11-10 05:38:53.000000000 -0800 *************** *** 1486,1491 **** --- 1486,1494 ---- mode_bits = scm_i_mode_bits (mode); } + #ifdef __APPLE__ + open_flags &= O_APPEND|O_SHLOCK|O_EXLOCK|O_CLOEXEC; + #endif SCM_SYSCALL (rv = mkostemp (c_tmpl, open_flags)); if (rv == -1) SCM_SYSERROR; The man page for mkstemp says the following: The mkostemp() function is like mkstemp() but allows specifying addi- tional open(2) flags (defined in <fcntl.h>). The permitted flags are O_APPEND, O_SHLOCK, O_EXLOCK and O_CLOEXEC. Note that macports includes another patch for Sierra: --- libguile/stime.c +++ libguile/stime.c @@ -834,6 +834,10 @@ scm_init_stime() #ifdef HAVE_POSIX_CPUTIME { +#ifdef __APPLE__ + if (clock_gettime (CLOCK_PROCESS_CPUTIME_ID, &posix_run_time_base) == 0) + get_internal_run_time = get_internal_run_time_posix_timer; +#else clockid_t dummy; /* Only use the _POSIX_CPUTIME clock if it's going to work across @@ -843,6 +847,7 @@ scm_init_stime() get_internal_run_time = get_internal_run_time_posix_timer; else errno = 0; +#endif } #endif /* HAVE_POSIX_CPUTIME */ #endif /* HAVE_CLOCKTIME */