guile-2.0.9's compiler has some inconvenient restrictions, relative to its interpreter. Where the compiler is automatically applied to scripts, the restrictions aren't a serious problem, because if compilation fails then guile falls back to interpreting the script. But in an interactive REPL session, by default each form entered by the user is passed through the compiler, and if compilation fails then the error is signalled, with no fallback to interpretation.
As a test case, consider a form in which a procedure object appears. The compiler can't handle forms that directly reference a wide variety of object types, including procedures (both primitive and user-defined) and GOOPS objects. In the interpreter these objects simply self-evaluate, and it can be useful to reference them without the usual indirection through a named variable. Here I'll show what happens to such a form in a script and interactively, in guile 1.8 and 2.0: $ cat t2 (cond-expand (guile-2 (eval-when (compile load eval) (fluid-set! read-eval? #t))) (else (fluid-set! read-eval? #t))) (define (p x y) (#.+ x y)) (write (p 2 3)) (newline) $ guile-1.8 t2 5 $ guile-2.0 --no-auto-compile t2 5 $ guile-2.0 t2 ;;; note: auto-compilation is enabled, set GUILE_AUTO_COMPILE=0 ;;; or pass the --no-auto-compile argument to disable. ;;; compiling /home/zefram/usr/guile/t2 ;;; WARNING: compilation of /home/zefram/usr/guile/t2 failed: ;;; ERROR: build-constant-store: unrecognized object #<procedure + (#:optional _ _ . _)> 5 $ guile-1.8 guile> (fluid-set! read-eval? #t) guile> (define (p x y) (#.+ x y)) guile> (p 2 3) 5 guile> ^D $ guile-2.0 GNU Guile 2.0.9-deb+1-1 Copyright (C) 1995-2013 Free Software Foundation, Inc. Guile comes with ABSOLUTELY NO WARRANTY; for details type `,show w'. This program is free software, and you are welcome to redistribute it under certain conditions; type `,show c' for details. Enter `,help' for help. scheme@(guile-user)> (fluid-set! read-eval? #t) scheme@(guile-user)> (define (p x y) (#.+ x y)) While compiling expression: ERROR: build-constant-store: unrecognized object #<procedure + (#:optional _ _ . _)> scheme@(guile-user)> (p 2 3) <unnamed port>:3:0: In procedure #<procedure 12bc9e0 at <current input>:3:0 ()>: <unnamed port>:3:0: In procedure #<procedure 12bc9e0 at <current input>:3:0 ()>: Unbound variable: p There is a workaround for this problem: the REPL's "interp" option controls whether forms go through the compiler or the interpreter. Hence: scheme@(guile-user)> (fluid-set! read-eval? #t) scheme@(guile-user)> (#.+ 2 3) While compiling expression: ERROR: build-constant-store: unrecognized object #<procedure + (#:optional _ _ . _)> scheme@(guile-user)> ,o interp #t scheme@(guile-user)> (#.+ 2 3) $1 = 5 So the problem is merely that the REPL is broken *by default*. It should either default to the working mechanism, or fall back to it when compilation fails (as the file auto-compilation does). Debian incarnation of this bug report: http://bugs.debian.org/cgi-bin/bugreport.cgi?bug=734108 -zefram