Just read this; there are some people resistant to
low-dose aspirin, so they need the regular 325mg/day:

http://my.webmd.com/content/Article/91/100970.htm?printing=true
"...The American Heart Association recommends aspirin
for patients with heart disease to lower the risks of
stroke or heart attacks. But it appears that some
people who take aspirin to protect their hearts are
resistant to its effects.  Studies have suggested that
as many as one in three people are aspirin resistant,
but new research hints that for many the problem may
be in the dosage.  Researchers from Chicago's
Northwestern Memorial Hospital tested 59 patients [a
tiny study!] who had strokes while on aspirin therapy
and found aspirin resistance in 73% of those taking a
low-dose baby aspirin (81 mg) compared with 32% of
those taking a regular-dose aspirin (325 mg) every
day...

"...Alberts says it is increasingly clear that aspirin
resistance is associated with an increased risk of
heart disease and strokes, but it is not yet clear if
resistant patients benefit from taking higher doses. 
Taking a daily, regular-dose aspirin is generally
considered safe for most people. The side effects of
aspirin, such as stomach irritation, stomach bleeding,
and bleeding into the brain are believed to increase
with higher doses, however.  But not everyone who
takes a particular dosage of aspirin achieves the same
level of heart protection, and it may be that not
everyone has the same bleeding risk... 

"...Another question that must be answered is which
test of aspirin resistance provides the most accurate
information, says cardiologist and American Heart
Association past president Valentin Fuster, MD. Until
recently, testing for aspirin resistance was laborious
and expensive, but there are now several quick and
relatively inexpensive tests available for use by
doctors in their offices.  The problem, Fuster says,
is that the tests tend to give different results...

"...He adds that the recent evidence showing less
resistance among patients taking a daily, 325 mg
aspirin tablet is compelling but not conclusive.  "I
now recommend 325 mg to my high-risk patients, and I
suspect that other clinicians are switching patients
from baby aspirin to regular aspirin," he says. "The
data don't yet prove that this should be done, but I
think it is reasonable." 


So if a person is at high risk for stroke or heart
attack, and does not have a history of bleeding
ulcers, it's probably prudent to use full-strength
aspirin daily, until better tests for aspirin
resistance are confirmed.

Debbi
An Apple A Day? Maru


                
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