*bio**intelligence** 13th**jan**2010*
BioGRID: A repository useful for Systems Biology
Systems Biology is emerging as one of the biggest research trends these
days. Talking about pathways, metabolomics, cellular cycles, interactions is
common in this field.
While reading on Interaction Datasets , I came across "*BioGrid*". Here is a
small post on the same.
BioGRID can be explained as *Biological General Repository for
Interaction Datasets*. It distributes collections of protein and genetic
interactions from major model organism species. BioGRID currently contains
over 198 000 interactions from six different species, as derived from both
high-throughput studies and conventional focused studies.
BioGRID interactions are recorded as relationships between two proteins or
genes (i.e. they are binary relationships) with an evidence code that
supports the interaction and a publication reference. The term “interaction”
includes, as well as direct physical binding of two proteins, co-existence
in a stable complex and genetic interaction. It should not be assumed that
the interaction reported in BioGRID is direct and physical in nature; the
experimental system definitions below indicate the nature of the supporting
evidence for an interaction between the two biological entities. It should
also be noted that some interactions in BioGRID have various levels of
evidential support. BioGRID simply curates the result of the experiment from
the publication and we do not guarantee that any individual interaction is
true, well-established or the current consensus view of the community.
Curating all available evidence supporting for an interaction enables
orthogonal data from various sources to be collated, allowing users of the
database to decide confidence in the existence and/or physiological
relevance of that interaction.
More information on Biogrid can be found at: www.thebiogrid.org
*
Regards,
Team Biointelligence
Biointelligence
Getting started with biosciences
Website: www.biointelligence.in
Email: [email protected]
Tel: +91-731-425-7930
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